Evaluation Alpinia galanga Essential Oil for  Anti Asthmatic Activity in Animal Models

 

Jyotsna Laksmhi Patil1, Suma US1*, Mamatha MK2 , Priya Shetti2

1KLEU’S college of pharmacy, Belgaum, Karnataka 590016

2Mallige college of pharmacy, Bangalore 560090

Abstract

The aim of the present study was to evaluate antiasthmatic activity of Alpinia galanga essential oil by using various animal models.Essential oil of Alpinia galanga was procured from GR herbals, Indore & Chemical analysis was carried out through GC-MS. In present study investigated the contraction inhibition activity on tracheal chain using histamine (10 μg/ml). For in vivo studies PCD time was observed in 0.1% histamine exposed guinea pigs. The present findings demonstrated significantly decrease the airway inflammation induced by ovalbumin. Hence the present study verified that A.galanga essential oil bearing antihistaminic, anti-inflammatory effect.

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Chemical Constituents From the Aerial Roots of Ficus benghalensis L.,  Leaves of Nyctanthes  arbor-tristis  L. and Roots of Verbesina encelioides  (Cav.) Benth. et Hook. f.

 

Shahnaz Sultana1,2, Mohammed Ali1*, Showkat Rassol Mir1

1Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110 062, India 

2Present address: College of Pharmacy, Jazan University, Jazan- 45142, Saudi  Arabia  

Abstract

Ficus benghalensis L. (Moraceae) is anative to tropical Asia. Its aerial roots are styptic and taken to alleviate biliousness, dysentery, liver inflammation, jaundice, spermatorrhoea, syphilis and obstinate vomiting.   Nyctanthes arbor-tristis  L. (Oleaceae)  is distributed in the  eastern  Asia including  India, Nepal, Pakistan, Thailand and  Indonesia. Its  leaves are  used to treat  acidity,  asthma,  bronchitis, cough,  dyspepsia,  fevers, hypertension,  malaria, menstrual cramps, piles,  rheumatism,  sciatica, snake bites, strangury and to  expel intestinal worms. Verbesina encelioides (Cav.) Benth. et Hook. f. (Asteraceae) is a native to southeastern North America and one of the most common weeds in northern India after the rainy season. Its roots are used to cure bladder inflammation and also as a blood purifier.  The air-dried plant parts were exhaustively extracted with methanol individually in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel for column and chromatographed over silica gel column separately. The columns were eluted with petroleum ether, chloroform and methanol successively to isolate the phytoconstituents. Phytochemical investigation of the aerial roots of F.  benghalensis afforded  n-tritriacontan-10-one (1),  30-lauryloxy- urs-12-en-3β-olyl butyrate (30-lauryloxy-α-amyrin 3-butyrate, 2) and  urs-12-en-23,6α-olide 3β-olyl palmitate (3-palmityl α-amyrin-23,6α-olide, 3). The leaves of N.  arbor-tristis  furnished two vanillyl glycosidic disters characterized as oleiyl-O-α-D-xylopyranosyl-(2a→1b)-O-α-D-xylopyranosyl-2b-vanillyl-4b-caproate (oleiyl-O-α-D-dixylosyl vanillyl caproate, 4) and oleiyl-O-α-D-arabinopyranosyl-(2a→1b)-O-α-D-arabinopyranosyl--(2b→1c)-O-α-D-arabinopyranosyl--(2c→1d)-O-α-D-arabinopyranosyl-2d-vanillyl-4d-caproate (oleiyl-O- α-D-tetra-arabinosyl vanillyl  caproate, 5). The roots of V.  encelioides produced  tetracosan-1-oyl   1-tetradecanoate (lignoceryl   myristate,  6), β-amyrin palmitate  (7), urs-12-en-3β-olyl oleate (β-amyrin oleate,  8) and  β-amyrin stearate (9). The structures of these phytoconstituents have been established on the basis of spectral data analysis and chemical reactions. 

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Nyctanthes arbortristis an Important Medicinal Plant of Madhya Pradesh State - A Review 

 

Ruchita Shrivastava1*, Ajay Kumar Bharadwaj2

1Deptt. Of Biotechnology, Institute for Excellence in higher education, Bhopal- 462016, MP, India

2N.M.B. Govt. College, Hoshangabad- 461001, MP, India  

Abstract

Medicinal plants are being widely used either as single drug or in combination for health care system. Nyctanthes arbortristis commonly known as night jasmine or Harshringar is an important medicinal plant mainly used in Ayurveda. It is one of the oldest system of medicines uses plants and their extracts for the treatment and management of various diseases. It has been reported as useful in sciatica, arthritis, fever, asthma, diabetes, cancer, etc. Plants contain various phytoconstituents belonging to the categories of glycosides, alkaloids, essential oils, tannins etc. Several studies are being carried towards its activities like antibacterial, antifungal, immunomodulatory, antipyretic, antioxidant and hepatoprotective properties. With all these potential benefits, this review is carried out to explore the hidden potential and its uses. This review explores the published scientific literature to compile all the traditional and scientific data of Nyctanthes arbortristis.

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Voyage into Curcumin Embedded Delivery Systems of Natural Polymers to Ameliorate Solubility and Bioavailability Limitations

 

Roopa G1, Roopa Karki2, Jayanthi C1*, Mukunthan S1, Hanumanthachar Joshi1, Goli Divakar2

1Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore, Karnataka, India

2Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Bangalore, Karnataka, India

Abstract

The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in south and southeast tropical Asia. The rhizome is coined as the most useful part of the plant and a staple in all cooking and treatment of medicinal purposes include antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-carcinogenic, anti-mutagenic and anti-inflammatory. It has a wide array of affinity to biological proteins and inhibits various kinases. Curcumin modulates the activity of several transcription factors, regulates the functioning of inflammatory enzymes, cytokines, adhesion molecules, and apoptic proteins. Recent preclinical and animal studies revealed the anti-proliferative, anti-invasive and antiangiogenic activity5,6. Clinically, Curcumin is proven to be safe while administering at larger doses, but due to poor aqueous solubility, quick systemic elimination, scanty tissue absorption and degradation at alkaline pH, which restrains its bioavailability, following strategies are used to enhance the bioavailability: (i) adjuvants like piperine which interferes with glucuronidation, (ii) liposomal curcumin, (iii) nanoparticles, (iv) Curcumin phospholipid complex and (v) structural analogues of curcumin. (VI) Micronisation and nanonisation (VII) self-microemulsifying drug delivery systems (SMEDDS), (vii) cyclodextrin inclusions, (IX) solid dispersions (X) Nanoemulsions, nanospheres, nanobeads, nanofibres7. The intention of this comprehension is to present a retrospective and prospective gist of applications of innovative delivery systems of Curcumin employed by the researchers to optimize Curcumin delivery using natural polymers with the objective of enhancing solubility and bioavailability, which might revolutionize the therapy of challenging chronic disorders of mankind.

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