Evaluation Alpinia galanga Essential Oil for Anti Asthmatic Activity in Animal Models
Jyotsna Laksmhi Patil1, Suma US1*, Mamatha MK2 , Priya Shetti2
1KLEU’S college of pharmacy, Belgaum, Karnataka 590016
2Mallige college of pharmacy, Bangalore 560090
Abstract
The aim of the present study was to evaluate antiasthmatic activity of Alpinia galanga essential oil by using various animal models.Essential oil of Alpinia galanga was procured from GR herbals, Indore & Chemical analysis was carried out through GC-MS. In present study investigated the contraction inhibition activity on tracheal chain using histamine (10 μg/ml). For in vivo studies PCD time was observed in 0.1% histamine exposed guinea pigs. The present findings demonstrated significantly decrease the airway inflammation induced by ovalbumin. Hence the present study verified that A.galanga essential oil bearing antihistaminic, anti-inflammatory effect.
HTML FULL TEXT PDF
Shahnaz Sultana1,2, Mohammed Ali1*, Showkat Rassol Mir1
1Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110 062, India
2Present address: College of Pharmacy, Jazan University, Jazan- 45142, Saudi Arabia
Abstract
Ficus benghalensis L. (Moraceae) is anative to tropical Asia. Its aerial roots are styptic and taken to alleviate biliousness, dysentery, liver inflammation, jaundice, spermatorrhoea, syphilis and obstinate vomiting. Nyctanthes arbor-tristis L. (Oleaceae) is distributed in the eastern Asia including India, Nepal, Pakistan, Thailand and Indonesia. Its leaves are used to treat acidity, asthma, bronchitis, cough, dyspepsia, fevers, hypertension, malaria, menstrual cramps, piles, rheumatism, sciatica, snake bites, strangury and to expel intestinal worms. Verbesina encelioides (Cav.) Benth. et Hook. f. (Asteraceae) is a native to southeastern North America and one of the most common weeds in northern India after the rainy season. Its roots are used to cure bladder inflammation and also as a blood purifier. The air-dried plant parts were exhaustively extracted with methanol individually in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel for column and chromatographed over silica gel column separately. The columns were eluted with petroleum ether, chloroform and methanol successively to isolate the phytoconstituents. Phytochemical investigation of the aerial roots of F. benghalensis afforded n-tritriacontan-10-one (1), 30-lauryloxy- urs-12-en-3β-olyl butyrate (30-lauryloxy-α-amyrin 3-butyrate, 2) and urs-12-en-23,6α-olide 3β-olyl palmitate (3-palmityl α-amyrin-23,6α-olide, 3). The leaves of N. arbor-tristis furnished two vanillyl glycosidic disters characterized as oleiyl-O-α-D-xylopyranosyl-(2a→1b)-O-α-D-xylopyranosyl-2b-vanillyl-4b-caproate (oleiyl-O-α-D-dixylosyl vanillyl caproate, 4) and oleiyl-O-α-D-arabinopyranosyl-(2a→1b)-O-α-D-arabinopyranosyl--(2b→1c)-O-α-D-arabinopyranosyl--(2c→1d)-O-α-D-arabinopyranosyl-2d-vanillyl-4d-caproate (oleiyl-O- α-D-tetra-arabinosyl vanillyl caproate, 5). The roots of V. encelioides produced tetracosan-1-oyl 1-tetradecanoate (lignoceryl myristate, 6), β-amyrin palmitate (7), urs-12-en-3β-olyl oleate (β-amyrin oleate, 8) and β-amyrin stearate (9). The structures of these phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.
HTML FULL TEXT PDFNyctanthes arbortristis an Important Medicinal Plant of Madhya Pradesh State - A Review
Ruchita Shrivastava1*, Ajay Kumar Bharadwaj2
1Deptt. Of Biotechnology, Institute for Excellence in higher education, Bhopal- 462016, MP, India
2N.M.B. Govt. College, Hoshangabad- 461001, MP, India
Abstract
Medicinal plants are being widely used either as single drug or in combination for health care system. Nyctanthes arbortristis commonly known as night jasmine or Harshringar is an important medicinal plant mainly used in Ayurveda. It is one of the oldest system of medicines uses plants and their extracts for the treatment and management of various diseases. It has been reported as useful in sciatica, arthritis, fever, asthma, diabetes, cancer, etc. Plants contain various phytoconstituents belonging to the categories of glycosides, alkaloids, essential oils, tannins etc. Several studies are being carried towards its activities like antibacterial, antifungal, immunomodulatory, antipyretic, antioxidant and hepatoprotective properties. With all these potential benefits, this review is carried out to explore the hidden potential and its uses. This review explores the published scientific literature to compile all the traditional and scientific data of Nyctanthes arbortristis.
HTML FULL TEXT PDF
Roopa G1, Roopa Karki2, Jayanthi C1*, Mukunthan S1, Hanumanthachar Joshi1, Goli Divakar2
1Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore, Karnataka, India
2Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Bangalore, Karnataka, India
Abstract
The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in south and southeast tropical Asia. The rhizome is coined as the most useful part of the plant and a staple in all cooking and treatment of medicinal purposes include antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-carcinogenic, anti-mutagenic and anti-inflammatory. It has a wide array of affinity to biological proteins and inhibits various kinases. Curcumin modulates the activity of several transcription factors, regulates the functioning of inflammatory enzymes, cytokines, adhesion molecules, and apoptic proteins. Recent preclinical and animal studies revealed the anti-proliferative, anti-invasive and antiangiogenic activity5,6. Clinically, Curcumin is proven to be safe while administering at larger doses, but due to poor aqueous solubility, quick systemic elimination, scanty tissue absorption and degradation at alkaline pH, which restrains its bioavailability, following strategies are used to enhance the bioavailability: (i) adjuvants like piperine which interferes with glucuronidation, (ii) liposomal curcumin, (iii) nanoparticles, (iv) Curcumin phospholipid complex and (v) structural analogues of curcumin. (VI) Micronisation and nanonisation (VII) self-microemulsifying drug delivery systems (SMEDDS), (vii) cyclodextrin inclusions, (IX) solid dispersions (X) Nanoemulsions, nanospheres, nanobeads, nanofibres7. The intention of this comprehension is to present a retrospective and prospective gist of applications of innovative delivery systems of Curcumin employed by the researchers to optimize Curcumin delivery using natural polymers with the objective of enhancing solubility and bioavailability, which might revolutionize the therapy of challenging chronic disorders of mankind.
HTML FULL TEXT PDF
