Extraction and Evaluation of Linseed Mucilage as Binding Agent in Prednisolone Tablet 20 mg
Alaa Balla Suliman Abuelrakha*, Elnazeer I. Hamedelniel
1 Faculty of Pharmacy, University of Omdurman Islamic (OIU), P.O. Box 382 Omdurman, Sudan
Abstract
Great interest been have develop to discover new excipients to solve problem that faced us during formulation like incompatibility and compressibility that lead to slow down manufacturing processes. Linseed mucilage has properties that suggested it as useful additives and binding agent like inertness, nontoxic and viscosity. The purpose of the present study was to extract and evaluate linseed mucilage as binding agent in prednisolone tablets. The Linseed mucilage was extracted and evaluated for physicochemical properties using official procedures. Tablet was prepared by wet granulation. Granules evaluation revealed satisfactory results. Three formula were prepared that contain three different percent from linseed mucilage 3%, 5% and 7%.The hardness test result show great increase in tablet hardness 4.23, 5.59 and 7.76, respectively. The dissolution test was carried in Ph 1.2 for 2 hours and cumulative drug release 20.33%, 17.88% and 14.49% respectively .And at Ph 6.8 for 4 hours cumulative drug release 78.18%, 75.43% and 69.19%. The tablets formulated showed acceptable general appearance. Formula mucilage 7% showed the best flowbility of granules, hardness and friability when compared with formulas 3% and 5%.In weight variation test indicated that the type and concentration of mucilage used were not significant. When increase the percent of mucilage in formula combined with increase in tablet hardness. Invitro dissolution study indicated that the main factors which influence the amount of drug released were the pH of the medium used and concentration of the mucilage.
HTML FULL TEXT PDFRecent Advances in Pharmacological and Phytochemistry Studies on Phyllanthus amarus
Mansi Gupta*, J S Vaghela
Bhupal Nobles‘ College of Pharmacy, Udaipur-313001, Rajasthan, India
Abstract
The use of medicinal plants for the treatment of various diseases has been increased due to minimum side effect compared to synthetic drug. Further the herbal products are considered as safe drugs. Phyllanthus amarus claimed tribal people for remedy of different diseases namely diarrhoea, dysentery, dropsy, jaundice, intermittent fevers, kidney problems, urinary bladder disturbances, pain, gonorrhea, diabetes, urogenital disorders, chronic dysentery, skin ulcers, sores, swelling, itchiness, tubercular ulcers, ringworm, scabies and wounds. Phyllanthus amarus contains isobubbialine, epibubbialine, securinine, nor-securinine, dihydrosecurinine, geraniin, corilagin, 1,6-digalloylglucopyranoside rutin , quercetin3-O-glucopyranoside, amarulone, niranthin, nirtetralin, phyltetralin, hypophyllanthin, phyllanthin, hypo-phyllanthin, demethylenedioxy-niranthin, kaempferol, astragalin, etc chemical constituents in its different parts. The extract of Phyllanthus amarus retains multiple pharmacological activities such as Anticarcinogenic, Antiproliferative, Gastroprotective, Cardioprotective, Antileptospiral, Antibacterial, Antidiabetic, Antiviral, Antivenom,Antiinflammatory etc. We planned to illustrate the recent studies appeared in Phytochemisty and Pharmacological activities of Phyllanthus amarus in order to highlight its multi-activity properties.
HTML FULL TEXT PDFPhytochemical and Pharmacological Aspects of Cucurbita moschata and Moringa oleifera
Sandhya Suresh*, S S Sisodia
Bhupal Nobles‘ College of Pharmacy, Udaipur-313001, Rajasthan, India
Abstract
Presently research on herbal drug has attracted a lot of attention globally. The herbal drugs are consisting of phytoconstituents that offer therapeutic effects against various diseases. Till date researchers reported significant potential of herbal drugs employed in various traditional, complementary and alternative systems. The pharmacological activity and phytochemical of several medicinal plants has been scientifically documented. Cucurbita moschata and Moringa oleifera are the medicinal plant and used as nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates and chemical entities for synthetic drug. The present review is useful for up-to date investigations on the medicinal activity of Cucurbita moschata and Moringa oleifera.
HTML FULL TEXT PDFIndian Medicinal Plants For Treatment of Ulcer: Systematic Review
Pahadiya Anitakumari Rambhai*, S S Sisodia
Bhupal Nobles‘ College of Pharmacy, Udaipur-313001, Rajasthan, India
Abstract
Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. Gastric ulcers occur commonly at old age and lower socio-economic class of individuals. At the present time many article gives a general idea of ulcer and its treatment by using synthetic drugs. But due to their limitation and side effects we no longer used synthetic drugs. According to published results, it can be said that medical plants are more affordable and have less side effects compared synthetic drugs, and are more effective in treatment of ulcer. India still depends on medicinal plants and they have played an important role in treatment and prevention of ulcers. This article will be concerned only the pharmacology of that plant which shows the antiulcer effects and among all the plants which one is more potent for anti-ulcer. Further investigations are needed to explore the more potent lead compounds with lesser side effects.
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