Conference Proceeding of National Seminar on Current Status and Future Scope for Nanomaterials and Nanotechnology in Drug Discovery and Development

 

Organized by Himachal Institute of Pharmaceutical Education and Research (HIPER), Nadaun Himachal Pradesh, India from 23-24 February 2018

Abstract

IInd National Seminaron “Current Status and Future Scope for Nanomaterials and Nanotechnology in Drug Discovery and Development” was organized by Himachal Institute of Pharmaceutical Education and Research (HIPER), Nadaun Himachal Pradesh, India from23-24 February 2018. The seminar was sponsored by Indian Council of Medical Research, New Delhi and Himachal Pradesh Technical University, Hamirpur. The conference invites all the participants across the various states of India to attend and share their insights and convey recent developments in the field of Pharmaceutical Nanotechnology. Nanotechnology seems to have gained a widespread interest in the recent years. This conference had a variety of keynote lectures, Oral Presentation, Poster Presentations, Scientific Quiz Competition and discussions with renowned speakers, Pharma and medical Professionals, healthcare Professionals and leading specialists involved in the field of Pharmaceutical Sciences.

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Protective Role  of Oral Bupropion in Prevention of Cataract Induced Experimentally  in Rabbits

 

Adeeb A. Al-Zubaidy1, Ahmed Majeed Rasheed2, Bahaa A. Abdul Hussien3, Dalia Abd Al-Kader Shakoor4*

1Al-Nahrain University, College of Pharmacy, Department of Pharmacology and Toxicology, Baghdad, Iraq

2Al-Nahrain University, College of medicine, Department of Surgery, Baghdad, Iraq

3Al-Qadesyiah University, College of Medical Vet., Department of Pharmacology,  Al-Qadesyiah, Iraq

4Al-Mustansiriyah University, College of Pharmacy, Department of Pharmacology and Toxicology, Baghdad, Iraq

Abstract

Cataract is one of the chief causes of blindness and visual impairment in the elderly people throughout the developing world. The aim of the study was to investigate the possible protective role of oral bupropion against selenite induced cataract in rabbits. Adult rabbits were used in the present study. Groups of study were: Apparently normal group, Cataract group and oral bupropion group. Cataract induction was done by a single intravitreal injection of 0.1 ml (0.01% w/v) of sodium selenite solution in the right eyes. Bupropion (50 mg/kg two times daily) was given for five days before intravitreal injection sodium selenite solution and 21 days after. The parameters were: Lens opacity, pupil diameter, light reflex, corneal sensation, conjunctival redness, the level of malondialdehyde (MDA) and reduced glutathione (GSH) in aqueous humor of rabbit eyes. Oral bupropion resulted in high significant protection from cataract development and there was no change in pupil diameter, positive light reflex, positive corneal sensation, no conjunctival redness, decreased level of MDA and increased level of GSH.

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Alterations in Zeta Potential and Osmotic Fragility of Red Blood Cells in Hyperglycemic Conditions

 

Swati S. Gaikwad*, Megha N. Karemore, Jasmine G. Avari

Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Mahatma Jyotiba Fuley Educational Campus, Amravati Road, Nagpur, 440033, Maharashtra, India

Abstract

The zeta potential is an electrokinetic property of red blood cells surface and in different disease conditions this property of the erythrocytes varies. The objective of the present study was to evaluate the alteration in zeta potential, lipid peroxidation and osmotic fragility of erythrocytes in hyperglycemic conditions.  The zeta potential of the RBCs was measured using Zeta meter System 4.0. Lipid peroxidation, an indicator of tissue injury induced by reactive oxygen species was measured by the thiobarbituric acid assay (TBA). The percent haemolysis in terms of osmotic fragility was determined using UV-Vis spectrophotometer (JASCO).The mean erythrocytic ZP of the control group was found to be 22.13±0.2789 mV whereas, erythrocytic ZP for diabetes mellitus patients was found to be 8.559±0.4864 mV. Similarly, when erythrocytic ZP of control pregnant women was measured, and it was found to be 21.07±0.3393 mV which were slightly lower than a control group. Mean ZP of GDM patients was found to be 10.12±0.2294 mV which was significantly less than both control group and pregnant control group. Variations in zeta potential values were accompanied by increased osmotic fragility of RBCs. It was also observed from determination of lipid peroxidation of erythrocytes, that there was formation of higher concentration of malondialdehyde with the erythrocytes of hyperglycemic patients compared to control group.The findings suggest that the zeta potential value of erythrocytes can act as a key indicator for demonstration of increased oxidative stress.

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Physicochemical, Phytochemical Screening and Antimicrobial Activity of Aegle marmelos

 

Asha Gupta1*, Tessy Thomas1, Shagufta Khan2

1Department of Botany, Govt. P.G. College, Sehore (MP)- 466001, India

2GrowTips Biotech, Saket Nagar, Bhopal (MP)- 462024, India

Abstract

The present study was aimed to evaluate the physicochemical, phytochemical screening and antimicrobial assessment of Aegle marmelos fruits extract. The powder was evaluated for loss on drying, alcohol extractive value and aqueous extractive value. The petroleum ether, ethanol and aqueous extract were prepared by soxhlet extraction process. The phytochemical analysis of extracts was performed, and antimicrobial activity of ethanol extracts against various strains was done. The loss on drying, alcohol and aqueous extractive values were 3.9%, 14.2% and 17.6%, respectively. Phytochemical analysis showed the presence of carbohydrates, alkaloids, glycoside, flavonoids, saponins, tannins phenols in ethanol extracts. The ethanol extracts demonstrated moderate to strong antimicrobial activity against S. epidermis, S. aureus, E. coli, P. aeruginosa and C. albicans. Thus in future, extract of Aegle marmelos may be beneficial for another several species of microbes.

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