Formulation and Evaluation of Mouth Dissolving Tablets of Tolperisone

 

  • Daljit Masih1*, Rajesh Gupta2

1J.J.T. University, Chudela, Jhunjhunu, (Rajasthan), India

2Sri Sai College of Pharmacy, Pathankot, (Punjab), India

 

Abstract

The present study was carried out to develop and evaluate mouth dissolving tablets of Tolperisone hydrochloride using superdisintegrants agents namely Crospovidone and Sodium starch glycolate in different ratio. Mouth dissolving tablets are solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue. The mouth dissolving tablets were prepared by direct compression method using Crospovidone and Sodium starch glycolate. Tablets blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like thickness, friability, hardness, weight variation, wetting time, water absorption ratio and disintegration test by using standard procedures. The results of all these tests were found to be satisfactory. The in-vitro dissolution study was carried out for 14 min using paddle method in phosphate buffer (pH 6.8) as dissolution media. The data of in-vitro dissolution of tablets revealed that 78 to 100% of drug release from various formulations at 14 min. The formulation T7 exhibited better results as compared to other formulations.

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Martynia annua: An Overview

 

Rameshroo Kenwat*, Pushpa Prasad, Trilochan Satapathy, Amit Roy

Department of Pharmacology, Columbia Institute of Pharmacy, Raipur-493111 (C.G.), India

Abstract

Martynia annua belongs to family Martyniaceae is an herbaceous annual plant, spread throughout India. It is commonly known as the Cats claw or Devils-claw. In India, traditional healers used M. annua in the treatment of epilepsy, inflammation, sore throat, burns, itching, skin affections and tuberculosis. M. annua contains alkaloids, tannins, saponins, glycosides, flavonoids, anthocyanins, amino acid, steroids and phenols. The researcher scientifically documented various pharmacological activities such as anthelmintic, analgesic, antipyretic, antibacterial, anti convulsant, antifertility, antinociceptive, antioxidant, CNS depressant, antidiabetic and wound healing activity of this plant. The reported activities make the plant in great interest among scholars to determine the mechanism of pharmacological activities of crude extracts. Hence the review paper outlines the previous research done on M. annua.

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Computation of In Vivo Antidiabetic Activity of Holarrhena antidysenterica Seeds Extracts in Streptozotocin-Induced-Diabetic Rats

 

Yakub Sheikh1*, Manish Singh Manral1, Vinod Kathait1, Bharat Prasar1, Rajesh Kumar2

1Department of Pharmaceutical Scienc

Abstract

Medicinal plants have curative properties due to the presence of various complex chemical compositions, which are found as secondary plant metabolites in one or more parts of the plant. The aim of this study was to computation the antidiabetic activity of Holarrhena antidysenterica seeds extract in streptozotocin-induced-diabetic rats. The experimental protocol designed as animals were divided into six groups (n=6) like normal, diabetic control, Glibenclamide, methanol extract (MEHAD), petroleum ether extract (PEHAD) and aqueous extract (AEHAD). Except normal group other remaining groups were treated with Streptozotocin (STZ) (35 mg/kg body weight) by single i.v. injection to induce diabetes. The diabetic rats were treated with the glibenclamide, MEHAD (250 mg/kg body weight), PEHAD (250 mg/kg body weight) and AEHAD (250 mg/kg body weight) for 18 days. The fasting plasma glucose level, body weight, fasting serum glucose level, serum cholesterol, serum triglyceride, total protein, blood urea, urine glucose and liver glycogen levels were determined. The diabetic rats treated with MEHAD, PEHAD and AEHAD showed significant reduction in fasting serum glucose, serum cholesterol, serum triglyceride, total protein, blood urea, urine glucose and protection from the loss of body weight and increase in liver glycogen content during the treatment period these effects were comparable to those seen in the glibenclamide treated group of rats. This suggests that the Holarrhena antidysenterica seed extracts posses antidiabetic activity and further studies are needed to elucidate the mechanism of action and to know the active principles involved in producing the effect.

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Mouth Dissolving Tablets - A Review

 

Daljit Masih1*, Rajesh Gupta2

1J.J.T. University, Chudela, Jhunjhunu, (Rajasthan), India

2Sri Sai College of Pharmacy, Pat

Abstract

Conventional dosage form such as tablets and capsules are the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing. However these dosage forms are facing problems like hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and in case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance. To overcome these problems, mouth dissolvingtablets have been developed, which having good hardness, dose uniformity, easy administration and serves as the first choice of dosage form for pediatrics, geriatrics and travelling patients. This report summarizes the details of ingredients used in preparation of mouth dissolving tablets; conventional manufacturing techniques for mouth dissolving tablets; patented technologies for preparation of mouth dissolving tablets;evaluation of mouth dissolving tablet; and mechanism of action of mouth dissolving tablets.

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Comparatives Evaluation of Antifertility Potential of Leaves of Bambusa arudinacea retz. and Ficus racemosa Bark Extracts in Female Albino Rats

 

Vishal Soni1*, Arvind Kumar Jha2, Jaya Dwivedi3, Priyanka Soni1

1Department of Herbal Drug Research, B.R. Naha

Abstract

Ethanol and hydroalcoholic (50%) extract of B. arundinacea leaves and 50 % ethanol extract of F. racemosa barks have been evaluated for antifertility activity in proven fertile rats at a dose of 200 and 400 mg/kg body weight. Plant extracts were tested for their effect on the estrous cycle at two dose level 200 and 400 mg/kg, respectively. Among these three extracts, the hydroalcoholic extracts of F. racemosa was found to be most effective in causing significant antiovulatory activity. The extract did not show any significant changes in structure and function of uterus when given alone, but when given along with ethinyl estradiol, it exhibited significant antiestrognic activity in immature female rats (P<0.001). Preliminary phytochemical screening of these two drugsshows the presence of carbohydrates, tannins, steroids, glycosides, flavonoids, phenolic, terpenoids etc. Histopathological studies of the uterus were carried out to confirm the estrogenic activity.

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A Review on Low Cost Methods for In Vitro Micropropagation of Plant Through Tissue Culture Technique

 

Jyoti Sahu*, Ram Kumar Sahu

Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), India

Abstract

Medicinal plants have been the subject of man`s curiosity since the time of human survival. A considerable majority of people of the world`s population still rely on the traditional medicine for their primary health care necessities. Currently demand of herbal medicines has been enhanced; and it is very difficult to fulfill the demand from field plants. Hence, in vitro propagation of plant by tissue culture can be used to fulfill the requirement of medicinal plants. The techniques applied in tissue culture are expensive; hence we try to summarize the data for low cost method for in vitro micropropagation of plant through tissue culture technique. This can help the scholar working in developing of tissue culture methods for in vitro propagation of medicinal plant.

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Phytochemical Screening and Antimicrobial Assessment of Leaves of Adhatoda vasica, Azadirachta indica and Datura stramonium

 

Amit Kumar Gupta, Nilesh Kumar Ahirwar, Nishant Shinde,

Manoj Choudhary, Yogendra Singh Rajput, Avineesh Singh

S.L.T Institute of Pharmaceutical Sciences, Guru Ghasid

Abstract

The present study was aimed to investigate the phytochemical screening and antimicrobial assessment of Adhatoda vasica, Azadirachta indica and Datura stramonium leaf extract.These plants were collected; aqueous and alcoholic extracts were prepared by soxhlet extraction process. The phytochemical analysis of extracts were performed, and antimicrobial activity of aqueous and alcoholic extracts of all plant material at dose of 100 mg/ml and 200 mg/ml concentrations against various strains were done. These extract were studied through agar diffusion method against E. coli, S. aureus, S. Bacillus bacteria and Rhizopus fungi and their comparison with standard ofloxacin. The phytochemical study inferred the presence of secondary metabolites which assist their herbal properties. Azadirachta indica was effective against all of these micro-organisms. While Adhatoda vasica and Datura stramonium were less effective as compared to Azadirachta indica and ineffective against Rhizopus fungi. Azadirachta indica had shown almost equal anti-microbial activity, against all species of microbes which was taken in study as compared to standard ofloxacin. Thus in future, extract of these plants may be beneficial for another several species of microbes and mixture of these plants may be more effective as compared to standard drugs.

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Pharmacognostical Studies of Amaranthus Spinosus Linn

 

Vipin Chandra Pal*, Om Veer Singh, Bhuwanendra Singh, Arshad Ahmad

Radha Govind Institute of Pharmacy, Chandausi, Moradabad (UP), India

Abstract

Amaranthus spinosus leaves species has been widely used as medicine in Ayurvedic system of medicine. Its leaves are used in treatment of malaria, hepatic disorders, fever, inflammation, leprosy, eczema, leucorrhoea and bronchitis. In view of its medicinal importance and taxonomic confusion, so here we determined the, microscopical structures along with powder characters of malaria, hepatic disorders, fever, inflammation, leprosy, eczema, leucorrhoea and bronchitis leaves. Fluorescence analysis, physico-chemical constants (total ash, acid insoluble ash, water soluble ash, ether soluble extractive, water soluble extractive, alcohol soluble extractive, foaming index) of leaves powder. Preliminary phytochemical investigation was carried out for the various crude extracts using solvent of different polarity. These studies provided referential information in regard to its identification parameters assumed significantly in the way of acceptability of herbal drugs in present scenario of lack of regulatory laws to control quality of herbal drugs.

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Preparation, Characterization and In-Vitro Cytotoxic Study of Doxorubicin PLGA Nanoparticles 

 

Bharat Parashar*, Sourabh Sharma

Manav Bharti University, Laddo, Solan-173229 (H.P.), India

Abstract

In the current study we had developed and characterized Poly (lactic-co-glycolide) acid nanoparticles for anticancer drug Doxorubicin and further studied in-vitro cytotoxic effect of free and encapsulated nanoparticle drug delivery system. PLGA-drug nanoparticles were prepared by oil-water emulsion solvent evaporation method. The morphology of drug loaded nanoparticles was analyzed using a scanning electron microscope. The drug loaded nanoparticles were evaluated for cell cytotoxicity by sulforhodamine B assay. Images of formulation indicate the surface morphology of formulation. The in vitro cytotoxicity results showed Doxorubicin NPs to be active against A431 and NCI-H322 cell line compared to Doxorubicin free drug. The IC50 values were found to be 1.73 µM with A431 cell line whereas 1.64 µM for NCI-H322 cell line. This indicates that Doxorubicin NPs have more pronounced activity towards A431cell line.

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