Evaluation of antidiabetic and antihyperlipidemic effects of Ougeinia oojeinensis in diabetic rats

 

Manohar Lal Samyal1,2*, Zabeer Ahmed2, Shashi Bhushan2, Asha Bhagat2, Toshita Mishra3, Manju Samyal4

1CMJ, University, Modrina Mansion, Laitumkhrah, Shillong-793003, (Meghalaya), India.

2IIIM Jammu, Canal Road, Jammu-180001, (J&K), India.

3Columbia Institute of Pharmacy, Raipur-493111 (C.G.), India

4Jammu Institute of Ayurveda & Research, Nardni, Raipur Bantalab Road, Jammu - 180001, India

Abstract

Ougeinia oojeinensis is a medicinal plant, used by herbalists for treating various diseases, one of which is diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of Ougeinia oojeinensis bark and root extracts. The different doses of ethanol extracts of bark and root were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of extracts, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of extracts on induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. The experimental data revealed that extract has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug.

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Potential Biological Spices Available in Bangladesh: A comprehensive review

 

Md. Reyad-ul-Ferdous1,2*, SM. Saddam Hossain2,Md. Nazmul Hasan2, Md. Moazzem Hossain2and Md. Abu HenaMostofa Kamal3

1Department of Pharmacy,Progati Medical Institute, Dhaka-1207, Bangladesh.

2Department of Pharmacy, North South University, Dhaka-1229, Bangladesh

3Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh.

Abstract

Nature is the major sources of natural medicines. Spices contain several phytochemical constituents which possess a variety of pharmacological activities. In advancement of technology of investigation research, the traditional plant spices assessment different properties can be done by new experimental researches, which have both human clinical trials and pre-clinical pharmacological animal experiments. Numerous studies indicate in past few decades, which proved digestive stimulatory, anti-inflammatory, antioxidant, anti diabetic, hypolipidemic, anti cancer, chemopreventive, anti mutagenic actions of a range of spices. Spices are used in the diet to provide advance natural treatment of mild to moderate diseases. Present studies suggested that several biologically active compounds can be discovered from those natural spices. Traditional studies show that Bangladeshi plants represent a vast resources for possible lead compound in drug development. This review indicates on the beneficial effects of spices in the management of several diseases. This review is advantageous to implement traditional and scientific knowledge together to use of some spices on several diseases.

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Dissolution behavior of poly vinyl alcohol in water and its effect on the physical morphologies of PLGA scaffolds

 

Adeyinka Aina1*, Andrew Morris1, Manish Gupta1, Nashiru Billa1, Neesha Madhvani2, Ritika Sharma2, Stephen Doughty1, Vivek Shah2, Yamina Boukari1

1Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia.

2School of pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom, NG7 2RD.

Abstract

Presented are data from a study of the aqueous properties of Poly Vinyl Alcohol (PVA), a well studied emulsifying agent, used in the preparation of biodegradeable Poly (DL-Lactide-Co-Glycolide) (PLGA) scaffolds/microparticles in water. How these properties affect the physical morphologies of PLGA scaffolds/microparticles produced from the various PVA solutions at different concentrations via the water emulsion synthetic method were also evaluated.

UV-Visible absorbance measurements showed a quantitative correlation between the estimated concentrations of PVA used in solution preparations and the actual concentrations in solution. The physical appearance/morphologies of the PLGA scaffolds produced from the different PVA solutions were the same irrespective of the concentration used.

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Preliminary Phytochemical Screening and In Vitro Antioxidant Efficacy of Fruit Oil of Martynia annua

 

Rameshroo Kenwat*, Pushpa Prasad, Ram Kumar Sahu, Amit Roy, Surendra Saraf

Department of Pharmacology, Columbia Institute of Pharmacy, Raipur-493111 (C.G.), India

Abstract

The free radicals play vital role in induction of various diseases. Natural antioxidants may help the body to protect itself from various types of oxidative damage which are linked to diseases such as cancer, diabetes, cardiovascular disorders and aging. Martynia annua belonging to Martyniaceae family are found to be a rich source of substances of phytochemical interest. The aim of the present study was to screen for phytoconstituent, and to determine the in vitro antioxidant activity of fruit oil of M. annua. The oil were extracted from fruit of M. annua by employing traditional methods. Preliminary phytochemical screening was performed to identify secondary metabolites in extracted oils. The in vitro antioxidant activity of oil was measured by means of the 1, 1-diphenyl-2-picrylhydrazyl (DPPH), Super oxide free radical scavenging assay and total polyphenol content. The phytochemical investigation of oil of M. annua revealed the presence of Alkaloids, glycosides, flavonoids, fats, tannins and phenolic compound. The oilstrongly scavenged DPPH radical and superoxide radical with the IC50 being 87.56 µg/ml and 106.80 µg/ml respectively. The oil of M. annua exhibited 87.25±1.13 mg/100 gm of total polyphenol content. The outcomes justifies the oil of M. annua is a potential source of natural antioxidants.

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Medicinal Plants Used in Liver Protection - A Review

 

Amit Roy1, Dayananda Bhoumik2*, Ram Kumar Sahu1, Jaya Dwivedi3

1Columbia Institute of Pharmacy, Tekari, Raipur (C.G.), India

2Oriental College of Pharmacy, Raisen Road, Bhopal (M.P.), India

3Department of Chemistry, Banasthali University, Rajasthan, India

Abstract

Liver is the very important part of our body responsible for the maximum metabolic and secretory activities and therefore appears to be a sensitive target site for substances modulating biotransformation. Liver is also associated in detoxification from the exogenous and endogenous challenges like xenobiotics, drugs, viral infections and chronic alcoholism. The period and intensity of the pharmacological response to drugs is influenced by their metabolic rate and hence substances capable to modify drug metabolism would be able to change the result of drug therapy. During all such exposures to the above mentioned challenges, if the usual defensive mechanisms of the liver are overpowered, the effect is liver damage. Liver injury or liver dysfunction is a major health problem that challenges not only medical professionals but also the pharmaceutical company and drug regulatory authorities. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption and microbes. Herbal medicines have been applied for the treatment of liver disorder for a lengthy period. Many herbal preparations are available in the market and therefore present review is aimed to compile the data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.

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An Overview on Phytochemistry and Pharmacological Explorations of Moringa oleifera

 

Surbhi Kesharwani*, Pushpa Prasad, Amit Roy, Ram Kumar Sahu

Columbia Institute of Pharmacy, Tekari, Raipur-493111 (C.G.), India

Abstract

Medicinal plants have been one of the prominent sources of remedies since the inception of human civilization. In rural area herbal medicines are considered to be best healthcare products due to it’s easily availability. Globally, demand of herbal based medicines, health products, pharmaceuticals, food supplements, cosmetics, etc. has been intensified in alarming rate. Moringa oleifera belongs to family Moringaecea, native of the Indian subcontinent, where its diverse parts have been employed throughout history as food and medicine. The M. oleifera is extensively used for treating cancer, hyperlipidemic, diabetic, ulcer, analgesic, fertility, convulsant, liver disorder, wound, etc. Dietary consumption of its part is therein promoted as a strategy of personal health preservation and self-medication in various diseases. The phytoconstituents present in this plant are niazirin, niazirinin, flavonoids, anthocyanins, proanthocyanidin, kaempferol-3-O-(6``- malonyl-glucoside), 4-hydroxymellein, β-sitosterone, octacosanic acid, β-sitosterol, etc. These various phytoconstituents contribute for different pharmacological activities. The present review is therefore, an effort to give a detailed overview of the published writings on phytochemistry and pharmacological activities of M. oleifera; this information will be beneficial in developing new formulations, which are more effective and have more therapeutic values.

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Scientific Validation of Antidiabetic Activity of Ethanol Extract of Ficus glomerata Barks and Roots in Streptozotocin-Induced Diabetic Rats

 

Manohar Lal Samyal1,2*, Zabeer Ahmed2, Shashi Bhushan2, Asha Bhagat2, Amit Das3, Manju Samyal4

1CMJ, University, Modrina Mansion, Laitumkhrah, Shillong-793003, (Meghalaya), India.

2IIIM Jammu, Canal Road, Jammu-180001, (J&K), India.

3 Bhupal Nobels` College of Pharmacy, Udaipur-313001, Rajasthan, India

4Jammu Institute of Ayurveda & Research, Nardni, Raipur Bantalab Road, Jammu - 180001, India

Abstract

The tribal people of Chhattisgarh state of India use Ficus glomerata for the treatment of diabetes therefore we planned to investigate antidiabetic effect of bark and root extract of bark and root in Streptozotocin (STZ)-induced diabetic rats.  Oral administration of ethanol extract of bark and root of Ficus glomerata at the doses of 200 and 400 mg/kg body weight was studied in STZ-induced diabetic rats.After administration of extract the fasting blood glucose levels were significantly decreased. The oral glucose tolerance was also improved. The effect of extracts on serum lipid profile like total cholesterol, triglycerides, low density lipoprotein (LDL) and high density lipoprotein (HDL) were also measured in the diabetic and non diabetic rats. There was significant reduction in total cholesterol, LDL and improvement in HDL in diabetic rats were observed. The activity of the plant extracts was comparable with glibenclamide, a well-known antidiabetic drug.These results indicated that Ficus glomerata possesses significant antidiabetic and antihyperlipidemic effect.

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