Qualitative Phytochemical Screenings of Methanol Extract of Parmentiera cereifera Seem Fruits

 

Md. Reyad-ul-ferdous1,2,3*, Md. Anisul Islam2, Fariha Tasnim3, Nawfel Abdullah4, Tamara Towshin Alam3, Saif Farhan Islam4

 1Department of Pharmacy, Progati Medical Institute, Dhaka-1207, Bangladesh.

2Department of Pharmacy, State University of Bangladesh, Dhaka 1205, Bangladesh.

3Department of Pharmacy, North South University, Dhaka-1229, Bangladesh.

4Department of Pharmacy, East West University, Dhaka-1219, Bangladesh.

Abstract

Nature is the best source of medicines. Plants consisting of various types of organic substances, and they impart different biological activities. The numerous medicines are administered to our body though diets. These foods protect us from different types of diseases and disorders. Here we planned to conduct phytochemical screening of the methanol extracts of Parmentiera cereifera fruit. The outcomes of phytochemical screening of methanol extracts exhibited the presence of flavonoids, saponins, tannins, triterpenoids as well as steroids. These phytoconstituents are used in ailment of various diseases such as antipyretic, analgesic, diabetes, cardioprotective, lipid lowering activity, hepatoprotective, antidiabetics, antidiarrhoeal, anticancer, antiasthmatic activities, antimicrobial etc. These are only preliminary studies to isolate potential compounds which may be use as a lead compound for several biological activities.

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TNF: A signaling pathway related to the activation of NF-κB

 

Noha Lotfy Ibrahim

Molecular Diagnostics and Therapeutics Department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt 

Abstract

Tumor necrosis factor (TNF or TNF-α) was formerly suggested as a circulating factor which can cause necrosis of tumors, before it has been known as a key regulator of some pleiotropic functions such as apoptosis, cell survival, inflammation, and immunity acting via two receptors (TNFR-1, TNFR-2). TNF-β or lymphotoxin (LT) has similar biologic effects as TNF-α; however it is produced in much smaller quantities and is a locally acting cytokine. This article discusses the biological function of TNF focusing on its role in cancer and autoimmune diseases via classical activation pathway of nuclear factor kappa-B (NF-κB).

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Chemical Characterization of the Flavonoid Constituents of Cuscuta reflexa 

 

Dandopani Chatterjee1*, Ram Kumar Sahu2

 1Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal (M.P.)-462021, India

2Columbia Institute of Pharmacy, Tekari, Raipur (C.G.)-493111, India

Abstract

The two new compounds were isolated by column chromatography from ethanol extract of the entire plant of Cuscuta reflexa. On the basis of IR, NMR and ES-MS spectroscopic analysis and by chemical transformation, structures of two compounds were elucidated as 3’-methoxy-3,4’,5,7-tetrahydroxy flavone and 3’-methoxy-4’,5,7-trihydroxy flavone-3-glucoside respectively. These isolated compounds were characterized by UV, IR, NMR and mass spectral studies.

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Evaluation of Antibacterial Activity and Drug Release Behavior of Chitosan-Based Nanofibers (In Vitro Study)

 

Hassan Nageh1, Metwally Ezzat1, Mohammed Ghanim1, Ahmed Hassanin2, Ahmed Abd El-Moneim1*

1Materials Science and Engineering Department, Egypt-Japan University of Science and Technology, New Borg El-Arab, Alexandria 21934, Egypt.

2Faculty of Engineering-Alexandria University-Egypt.

Abstract

Spinning of chitosan-poly (vinyl alcohol); Cs/PVA and chitosan- poly (caprolactone); Cs/PCL polymer blends were successfully achieved using electrospinning technique. The nanofiber mats of Cs/PVA and Cs/PCL were used as carriers for examining the release profile of Ciprofloxacin.HCl as broad-spectrum antibiotic. The shape, size, structure and composition of the nanofibers were characterized using FT-IR Spectroscopy and Scanning Electron Microscope (SEM). The release behavior was studied in Phosphate Buffer Solution (pH=7.4) using a UV-spectrophotometer. The antimicrobial activity of the produced nanofiber mats was studied using different strains of human pathogenic bacteria and Fungi. Compared to release profile from Cs/PVA/Ciprofloxacin.HCl nanofibers show faster drug release than that of Cs/PCL/Ciprofloxacin.HCl system,indicating that these nanofiber mats are promising active wound dressing materials for wound dressing applications.

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Curcumin Encapsulated Alginate/Pluronic Block Copolymer Micelles as a Promising Therapeutic Agent

 

Franklin John a and Jinu George *a

aBiotechnology Laboratory, Department of Chemistry,Sacred Heart college, Mahatma Gandhi University,Thevara, INDIA 

Abstract

Curcumin in turmeric is responsible for most of the therapeutic effects exhibited by this natural product. Solubility of this dietary compound is very low in water at neutral pH and room temperature, which decreases its bioavailability. This in turn proves to be a major setback in making use of curcumin as a therapeutic agent against many diseases, including cancer. Alginate/Pluronic® tri-block copolymer P123 micelles has the potential for the formulation of curcumin. Inner core of the micelles effectively trap-free curcumin as evidenced by analytical data. The drug-encapsulated micelles were spherical in shape with diameters below 100 nm and found to be spherical particles with an average size of 50–100 nm, being suitable for drug delivery applications. Release profile of curcumin was investigated in aqueous PBS solution at pH 7.4 (37 ± 0.2 ºC). Fitting of drug release data in the Korsmeyer–Peppas model suggested sustained release with diffusion mechanism (0.5 < n). The in vitro cytotoxicity of the drug formulation was investigated with L 929 cancer cells. Polymer encapsulated curcumin showed comparable anticancer activity with free Cur.

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