Synthesis Of Gum Tragacanth-Cl-Poly (Acrylic Acid) Superabsorbent Hydrogels with Salt, pH and Electrical Responsive Properties
Department of Pharmacy, MN DAV Dental College, Solan, 173212 (H.P), India
Received: 14-May-2017 , Accepted: 10-Oct-2017
Keywords: Colon specific targeting, Hydrogel, Glutaraldehyde, Salt resistant, Electrical responsive properties
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Deepak Prashar. Synthesis Of Gum Tragacanth-Cl-Poly (Acrylic Acid) Superabsorbent Hydrogels with Salt, pH and Electrical Responsive Properties. UKJPB. 2017; 5(5): 06-13.
The Gum tragacanth-acrylic acid-based hydrogels were prepared using KPS-ascorbic acid as an initiator and glutaraldehyde as crosslinker via free radical graft copolymerization technique. Synthesized polymers were characterized with FTIR, SEM and thermal techniques in order to authenticate the grafting of poly (AA) on to Gum tragacanth. The candidate’s hydrogel was also evaluated for salt resistant distension studies by means of biological electrolytic system using AC/DC supply. Moreover, the re-swelling ability of the candidate polymer was also studied using different pH media for its utilization in the site specific drug delivery. The results of the study suggested that the candidate polymer shows good salt resistant behavior alongwith pulsatile (swelling/de-swelling) nature. From the results of present study it was concluded that thepolymer can beutilized for targeted drug delivery system as carrier.