Risk Factors, Management and Other Correlates of Peptic Ulcer Disease in a University Community in South-South Nigeria

Eniojukan JF1*, Okonkwo OC2 and Adje UD2

1Department of Clinical Pharmacy and Pharmacy Practice, Niger Delta University, PMB 071, Wilberforce Island, Bayelsa State, Nigeria

2Department of Clinical Pharmacy and Pharmacy Administration, Delta State University, PMB 1, Abraka, Delta State, Nigeria

Received: 01-Dec-2017 , Accepted: 20-Dec-2017

Keywords: Peptic Ulcer Disease, Prevalence, Patterns, Management, Nigeria

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Risk Factors, Management and Other Correlates of Peptic Ulcer Disease in a University Community in South-South Nigeria. UKJPB. 2017;5(6): 07-15.

Abstract

The most common causes of peptic ulcer disease (PUD) are Helicobacter pylori infection and use of non-steroidal anti-inflammatory drugs (NSAIDs).Treatment choices include standard triple therapy. This study evaluated the patterns of prevalence, life-style risk factors and correlates of management of PUD among Staff and Students of Delta State University, Abraka Campus, Nigeria. A descriptive cross sectional study was initiated among 450 willing staff and student respondents. A total of 126 respondents that had been diagnosed for PUD were further evaluated for prevalence and patterns, confounding life-style factors, drug therapy and other correlates of PUD management by using self-designed, pre-tested questionnaires that addressed the objectives of the study. Data was analyzed using Statistical Package for Social Sciences, version16.0 (SPSS Inc. Chicago Illinois). Duodenal Ulcer (DU) had a higher prevalence than Gastric Ulcer (GU) in a ratio of 1.5:1. The prevalence of GU was higher among Staff, Males and those older than 35 years; DU had a higher prevalence among the Students, Females and 16-35 yrs age group. The greatest life-style risk factors identified were consumption of NSAIDs, Tobacco and Alcohol. Regarding drug treatment, over 90% of drugs prescribed were antibiotics; nearly all respondents claimed to experience side-effects which included Diarrhea, Abdominal Pain and Headache; nearly all respondents often adhered to instructions to avoid Alcohol. In this population, PUD prevalence and pattern was structured along gender and age. There were issues with life-styles which could have contributed to the pathophysiology of PUD. Patients experienced some side-effects that affected adherence to instructions. Management seemed appropriate with the use of triple therapies. However, there is still a dire need for strategic health education on PUD risk factors and self-care practices.