Antioxidant, Anti-alzheimer and Anti-parkinson activity of Artemisia nilagirica Leaves with Flowering Tops
Pradeep Pal1*, A.K. Ghosh2
1Mahakal Institute of Pharmaceutical Studies, Ujjain (M.P.)-456664, India
2IFTM University, Muradabad (U.P.)- 244102, India
Received: 05-Jan-2018 , Accepted: 30-Mar-2018
Keywords: Artemisia nilagirica, Anti-alzheimer, Anti-parkinson, Antioxidant
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How to Cite this Article
Pal P, Ghosh AK. Antioxidant, Anti-alzheimer and Anti-parkinson activity of Artemisia nilagirica Leaves with Flowering Tops. UKJPB. 2018; 6(2):12-23.
Presently peoples are loaded with stress and leads to various neurodegenerative disorders like anxiety, Alzheimer’s disease and Parkinson’s disease. The present study was aimed to investigate the antioxidant, anti-alzheimer and anti-parkinson activity of Artemisia nilagirica leaves with flowering tops extracts. The ethanol and aqueous extracts of Artemisia nilagirica leaves with flowering tops were processed for evaluation of in vitro antioxidant activity namely hydrogen-donating activity, superoxide scavenging activity, total polyphenol content, total flavonol content and reducing power assay. The object recognition and Y-Maze test were used to evaluate the anti-alzheimer`s activity of extract. The different parameters like catalepsy (bar test), locomotor activity (actophotometer test), and muscle activity (rotarod test) were measured in all animals for anti-parkinson activity. The findings of in vitro antioxidant study demonstrated that ethanol extract has maximum antioxidant properties compared to aqueous extract. Hence the ethanol extract of Artemisia nilagirica was selected for screening of anti-alzheimer and anti-parkinson activity. The administration of ethanol extract of Artemisia nilgirica exhibited significant anti-alzheimer and anti-parkinson activity. The findings of anti-alzheimer and anti-parkinson activity ethanol extract of Artemisia nilagirica demonstrated that this plant have neuroprotective properties.