Extraction and Evaluation of Linseed Mucilage as Binding Agent in Prednisolone Tablet 20 mg

Alaa Balla Suliman Abuelrakha*, Elnazeer I. Hamedelniel

1 Faculty of Pharmacy, University of Omdurman Islamic (OIU), P.O. Box 382 Omdurman, Sudan

Received: 06-Dec-2018 , Accepted: 16-Jan-2019

Keywords: Extraction, Evaluation, Linseed, mucilage, Binding agent

DOI: http://dx.doi.org/10.20510/ukjpb/7/i1/179296

 

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How to Cite this Article

Alaa Balla Suliman Abuelrakha, Elnazeer I. Hamedelniel. Extraction and Evaluation of Linseed Mucilage as Binding Agent in Prednisolone Tablet 20 mg. PBJ. 2019; 7(1): 09-14.

Abstract

Great interest been have develop to discover new excipients to solve problem that faced us during formulation like incompatibility and compressibility that lead to slow down manufacturing processes. Linseed mucilage has properties that suggested it as useful additives and binding agent like inertness, nontoxic and viscosity. The purpose of the present study was to extract and evaluate linseed mucilage as binding agent in prednisolone tablets. The Linseed mucilage was extracted and evaluated for physicochemical properties using official procedures. Tablet was prepared by wet granulation. Granules evaluation revealed satisfactory results. Three formula were prepared that contain three different percent from linseed mucilage 3%, 5% and 7%.The hardness test result show great increase in tablet hardness 4.23, 5.59 and 7.76, respectively. The dissolution test was carried in Ph 1.2 for 2 hours and cumulative drug release 20.33%, 17.88% and 14.49% respectively .And at Ph 6.8 for 4 hours cumulative drug release 78.18%, 75.43% and 69.19%. The tablets formulated showed acceptable general appearance. Formula mucilage 7% showed the best flowbility of granules, hardness and friability when compared with formulas 3% and 5%.In weight variation test indicated that the type and concentration of mucilage used were not significant. When increase the percent of mucilage in formula combined with increase in tablet hardness. Invitro dissolution study indicated that the main factors which influence the amount of drug released were the pH of the medium used and concentration of the mucilage.