Archive Details

Pahadiya Anitakumari Rambhai*, S S Sisodia

Bhupal Nobles‘ College of Pharmacy, Udaipur-313001, Rajasthan, India

Abstract

Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. Gastric ulcers occur commonly at old age and lower socio-economic class of individuals. At the present time many article gives a general idea of ulcer and its treatment by using synthetic drugs. But due to their limitation and side effects we no longer used synthetic drugs. According to published results, it can be said that medical plants are more affordable and have less side effects compared synthetic drugs, and are more effective in treatment of ulcer. India still depends on medicinal plants and they have played an important role in treatment and prevention of ulcers. This article will be concerned only the pharmacology of that plant which shows the antiulcer effects and among all the plants which one is more potent for anti-ulcer. Further investigations are needed to explore the more potent lead compounds with lesser side effects.

Sandhya Suresh*, S S Sisodia 

Bhupal Nobles‘ College of Pharmacy, Udaipur-313001, Rajasthan, India

Abstract

Presently research on herbal drug has attracted a lot of attention globally. The herbal drugs are consisting of phytoconstituents that offer therapeutic effects against various diseases. Till date researchers reported significant potential of herbal drugs employed in various traditional, complementary and alternative systems. The pharmacological activity and phytochemical of several medicinal plants has been scientifically documented. Cucurbita moschata and Moringa oleifera are the medicinal plant and used as nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates and chemical entities for synthetic drug. The present review is useful for up-to date investigations on the medicinal activity of Cucurbita moschata and Moringa oleifera.

Mmehibe FO¹, Alagwu ND², Ngwu EE², Alagwu EA²

¹Department of Physiology, College of Medicine, Abia State University, P.M.B 2000, Uturu, Abia State, Nigeria

²Department of Physiology, College of Medicine, Imo State University, P.M.B 2000, Owerri, Imo State, Nigeria

Abstract

Respiratory and Non-respiratory symptoms/sign in exposed Camphor industrial workers in Aba, Abia State, South East Nigeria, were studied. 100 selected Igbo women, working in Camphor industry for over 15 years were studied and they constitute the test group. They were compared with control subjects not exposed to Camphor or any known air pollutants. Both subjects were aged 25-50 years and weighed between 50-70 kg. Respiratory symptoms studied include dry unproductive cough, productive sputum cough, running/nasal congestion, sneezing, breathlessness, wheeze and chest pain. Non-respiratory symptoms investigated include feeling hot, general body pain, waist pain, internal heat, night fever, excessive sweating, occasional vomiting, abdominal ache, heat rashes, insomnia and blood pressure. The study lasted 3 months and was carried out using questionnaires and other necessary instruments after obtaining their consents. Results obtained showed that all respiratory symptoms in the study subjects (test) were highly significant when compared with control subjects (P<0.001). In non-respiratory symptoms, vomiting, abdominal ache and blood pressure in both the test and control were not statistically significant (P>0.05), others were statistically significant when the test subjects were compared with control (P<0.05). It was concluded that Camphor has significant effects on respiratory and non-respiratory symptoms/signs in exposed Camphor industrial workers.

Jyotsna Laksmhi Patil¹, Suma US¹*, Mamatha MK² , Priya Shetti²

¹KLEU’S college of pharmacy, Belgaum, Karnataka 590016

²Mallige college of pharmacy, Bangalore 560090

Abstract

The aim of the present study was to evaluate antiasthmatic activity of Alpinia galanga essential oil by using various animal models.Essential oil of Alpinia galanga was procured from GR herbals, Indore & Chemical analysis was carried out through GC-MS. In present study investigated the contraction inhibition activity on tracheal chain using histamine (10 μg/ml). For in vivo studies PCD time was observed in 0.1% histamine exposed guinea pigs. The present findings demonstrated significantly decrease the airway inflammation induced by ovalbumin. Hence the present study verified that A.galanga essential oil bearing antihistaminic, anti-inflammatory effect.

Shahnaz Sultana^1,2, Mohammed Ali^1*, Showkat Rassol Mir¹

¹Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi - 110 062, India 

²Present address: College of Pharmacy, Jazan University, Jazan- 45142, Saudi  Arabia  

Abstract

Ficus benghalensis L. (Moraceae) is anative to tropical Asia. Its aerial roots are styptic and taken to alleviate biliousness, dysentery, liver inflammation, jaundice, spermatorrhoea, syphilis and obstinate vomiting.   Nyctanthes arbor-tristis  L. (Oleaceae)  is distributed in the  eastern  Asia including  India, Nepal, Pakistan, Thailand and  Indonesia. Its  leaves are  used to treat  acidity,  asthma,  bronchitis, cough,  dyspepsia,  fevers, hypertension,  malaria, menstrual cramps, piles,  rheumatism,  sciatica, snake bites, strangury and to  expel intestinal worms. Verbesina encelioides (Cav.) Benth. et Hook. f. (Asteraceae) is a native to southeastern North America and one of the most common weeds in northern India after the rainy season. Its roots are used to cure bladder inflammation and also as a blood purifier.  The air-dried plant parts were exhaustively extracted with methanol individually in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel for column and chromatographed over silica gel column separately. The columns were eluted with petroleum ether, chloroform and methanol successively to isolate the phytoconstituents. Phytochemical investigation of the aerial roots of F.  benghalensis afforded  n-tritriacontan-10-one (1),  30-lauryloxy- urs-12-en-3β-olyl butyrate (30-lauryloxy-α-amyrin 3-butyrate, 2) and  urs-12-en-23,6α-olide 3β-olyl palmitate (3-palmityl α-amyrin-23,6α-olide, 3). The leaves of N.  arbor-tristis  furnished two vanillyl glycosidic disters characterized as oleiyl-O-α-D-xylopyranosyl-(2a→1b)-O-α-D-xylopyranosyl-2b-vanillyl-4b-caproate (oleiyl-O-α-D-dixylosyl vanillyl caproate, 4) and oleiyl-O-α-D-arabinopyranosyl-(2a→1b)-O-α-D-arabinopyranosyl--(2b→1c)-O-α-D-arabinopyranosyl--(2c→1d)-O-α-D-arabinopyranosyl-2d-vanillyl-4d-caproate (oleiyl-O- α-D-tetra-arabinosyl vanillyl  caproate, 5). The roots of V.  encelioides produced  tetracosan-1-oyl   1-tetradecanoate (lignoceryl   myristate,  6), β-amyrin palmitate  (7), urs-12-en-3β-olyl oleate (β-amyrin oleate,  8) and  β-amyrin stearate (9). The structures of these phytoconstituents have been established on the basis of spectral data analysis and chemical reactions. 

Ruchita Shrivastava^1*, Ajay Kumar Bharadwaj²

¹N.M.B. Govt. College, Hoshangabad- 461001, MP, India

²Deptt. Of Biotechnology, Institute for Excellence in Higher Education, Bhopal- 462016, MP, India

Abstract

Medicinal plants are being widely used either as single drug or in combination for health care system. Nyctanthes arbortristis commonly known as night jasmine or Harshringar is an important medicinal plant mainly used in Ayurveda. It is one of the oldest system of medicines uses plants and their extracts for the treatment and management of various diseases. It has been reported as useful in sciatica, arthritis, fever, asthma, diabetes, cancer, etc. Plants contain various phytoconstituents belonging to the categories of glycosides, alkaloids, essential oils, tannins etc. Several studies are being carried towards its activities like antibacterial, antifungal, immunomodulatory, antipyretic, antioxidant and hepatoprotective properties. With all these potential benefits, this review is carried out to explore the hidden potential and its uses. This review explores the published scientific literature to compile all the traditional and scientific data of Nyctanthes arbortristis.

Roopa G¹, Roopa Karki², Jayanthi C^1*, Mukunthan S¹, Hanumanthachar Joshi¹, Goli Divakar²

¹Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore, Karnataka, India

²Department of Pharmaceutics, Acharya and BM Reddy College of Pharmacy, Bangalore, Karnataka, India

Abstract

The turmeric (Curcuma longa) plant, a perennial herb of the ginger family, is an agronomic crop in south and southeast tropical Asia. The rhizome is coined as the most useful part of the plant and a staple in all cooking and treatment of medicinal purposes include antioxidant, anti-viral, anti-bacterial, anti-fungal, anti-carcinogenic, anti-mutagenic and anti-inflammatory. It has a wide array of affinity to biological proteins and inhibits various kinases. Curcumin modulates the activity of several transcription factors, regulates the functioning of inflammatory enzymes, cytokines, adhesion molecules, and apoptic proteins. Recent preclinical and animal studies revealed the anti-proliferative, anti-invasive and antiangiogenic activity^5,6. Clinically, Curcumin is proven to be safe while administering at larger doses, but due to poor aqueous solubility, quick systemic elimination, scanty tissue absorption and degradation at alkaline pH, which restrains its bioavailability, following strategies are used to enhance the bioavailability: (i) adjuvants like piperine which interferes with glucuronidation, (ii) liposomal curcumin, (iii) nanoparticles, (iv) Curcumin phospholipid complex and (v) structural analogues of curcumin. (VI) Micronisation and nanonisation (VII) self-microemulsifying drug delivery systems (SMEDDS), (vii) cyclodextrin inclusions, (IX) solid dispersions (X) Nanoemulsions, nanospheres, nanobeads, nanofibres⁷. The intention of this comprehension is to present a retrospective and prospective gist of applications of innovative delivery systems of Curcumin employed by the researchers to optimize Curcumin delivery using natural polymers with the objective of enhancing solubility and bioavailability, which might revolutionize the therapy of challenging chronic disorders of mankind.