Physical Properties and Compactability of Various Blends of Fully Gelatinised and Pregelatinised Maize Starch

 

Jimmy Ronald Angupale1, Ogwang Patrick Engeu2, Okafor Sylvester Ignatius1

1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, PMB 2084, Jos 930001, Nigeria

2Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology, P.O Box 1410, Mbarara – Uganda

Abstract

The use of pregelatinised maize starch in direct compression as a sole binder produces tablets with relatively low tensile strength. Fully gelatinised maize starch possesses better binding properties but its use is limited in immediate release tablets. The aim of this work was to prepare a blend of fully gelatinised and pregelatinised maize starch possessing optimum tabletting properties. The pregelatinised starch was prepared by heating a 15 % slurry at 65 ℃ for 15 min followed by filtration and drying. The fully gelatinised starch was prepared by heating a 10 % slurry at 80 ℃ for 5min followed by precipitation with acetone, filtration and drying. The two samples were blended in 100:0, 25:75, 50:50, 75:25 and 0:100 proportions. Both local and BP starch samples were used and their blends compared for flow, packing characteristics and compactability. The disintegration time of the compacts was also determined. The results indicated that the BP starch blends exhibited better tabletting properties compared to the local starch. The proportion with 100 % fully gelatinised starch showed the best flow and compactability. Compacts containing 50:50 modified starch blends and those containing higher pregelatinised starch content disintegrated within 15 min. The fully gelatinised starch had better tabletting characteristics though physical mixing of the powder sample with pregelatinised starch may not improve the binding properties of the latter, and it could be used for immediate release tablets in such blends at a concentration of <50%.

HTML FULL TEXT    PDF    XML 

Analysis of Some Hematological and Biochemical Markers in Women Cancer Patients Receiving Doxorubicine Chemotherapy

 

Boulaares Islam*, Guemari Imane Yousra, Derouiche Samir 

Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life,  El-Oued University, El-Oued 39000, El Oued, Algeria

Abstract

The goal of this study is to evaluate the effect of Doxorubicine chemotherapy on some biochemical and hematological markers in female cancer`s patients. 22 cases of women cancer and control were chosen, Blood samples were collected from them and lipid profile, creatinine, urea levels and enzyme activities were measured. Also, erythrocyte and leucocyte line levels in blood was measured. Results of biochemical parameters revealed that a significant increase in serum lipid profile, creatinine level, LDH, GOT, GPT and GGT activities and no significant change in serum urea level in women with cancer compared to controls. On the other hand,  Results of the haematological analysis show that RBC, HGB, HCT and lymphocyte (p <0.01) level are significant decreased in patients compared to control group and no significant change in WBC, Neutrophil , Monocyte , Eosinophil and basophile in patients compared to control group. In conclusion, the present study suggests that doxorubicin affect some biochemical and hematological marker of cardiac function indicating the cardiotoxic as a side effect of this treatment in cancer patients.

HTML FULL TEXT    PDF    XML 

Different Approaches of Continuous Fascial Iliaca Compartment Block Under Ultrasound-Guidance for Hip Arthroplasty: Short axis vs long axis in-Plane Techniques

 

Ahmed Ali Ebshena1, Mei Wei2

1Department of Anesthesiology Practice, Tongji Medical College, Tongji Hospital, Wuhan, Hubei 430074, P.R. China
2Department of Anesthesiology Practice,Professor, Tongji medical College, Tongji Hospitals Wuhan-430074, China

Abstract

Continuous Fascia iliaca compartment block provides effective analgesia by effective blockade of the femoral and lateral femoral cutaneous (LFC) in patients undergoing hip orthopedic surgeries. We compared analgesic effect of ultrasound-guided continuous fascia iliaca compartment block using either a short-axis in-plane technique or a long-axis in-plane technique for patients undergoing hip arthroplasty.In this prospective double-blind study, twenty-six ASA- I and II patients undergoing hip orthopedic surgeries were enrolled and randomly assigned to receive continuous fascia iliaca compartment block with either a short axis in-plane or a long-axis in- plane technique. The perineural catheter was attached to an electronic infusion pump. Ropivacaine 0.2% was administered through the catheter for 48 hours (4 mL/h). The primary outcome was ropivacaine consumption within 48h in the two groups. Secondary outcomes included the procedural time, success rate of block, postoperative pain score evaluated by NRS score at rest and movement. There was no significant difference in the consumption of ropivacaine during the 48 postoperative hours (P>0.05). Short-axis in-plane group need less procedural time for catheterization insertion than long-axis group. Compared with the short-axis in-plane technique, long-axis in-plane continuous fasicia iliaca compartment block had no ropivacaine-sparing effect on patient-controlled analgesia for hip arthroplasty.

HTML FULL TEXT    PDF    XML 

Physical-Chemical Characterization and Thin Layer Chromatographic Comparison of a Local Propolis with the Mangifera indica Resin

 

Dailen Guanche Gallardo*, Mario Fajardo, Yaneisy Naranjo Alonso, Lilian San Martín Echemendía, Jam Montalvan Copello

Beekeeping Research Center. El Cano. Arroyo Arenas. La Lisa, Postal Code 19190, Havana City, Cuba

Abstract

Mango (Mangifera indica) is an abundant tree of Cuban flora that is known for many healing properties and a deposit of bees as a source of raw materials for the propolis production. This work aimed to determine if the resin of mango felled bark was used by honeybees in the elaboration of a specific type of propolis. This could be possible by qualitatively comparison of its samples with the mango resin and the quality of this propolis through its physicochemical characteristics. To do this, propolis was collected and hydroalcoholic extracts were prepared. From this, botanical origin was determined by the technique of thin layer chromatography. Humidity, oxidation index, wax, resin and mechanical mixtures were evaluated from raw material. Results demonstrated that the samples of propolis collected presented a chromatographic profile similar to mango resin. In the samples of propolis, it was determined that quercetin and mangiferin are present in their qualitative composition of secondary metabolites. On the other hand, the mango propolis satisfies the requirements established by international regulations for good quality propolis in terms of humidity, oxidation index and mechanical mixtures.

HTML FULL TEXT    PDF    XML 

Study of Poisoning Cases Presenting in Emergency Department of Medical Teaching Hospital in Libya

 

Zubaeda. M. Mohamed Alsayeh1*, Ahmed Ali EBshena2

1Department of Pharmacology and Toxicology, Zubaeda Alsayeh,University of Zawia, Faculty of Pharmacy, Az Zawiyah, Libya

2Department of Anesthesiology Practice, Ahmed EBshena, Al Gmail government public hospital, Gm Al Gmail, Libya

Abstract

Poisoning is the emergence of unfavourable signs and symptoms inthe body after exposure to harmful chemical, physical or drugs substances, the current study, we evaluated risk factors and treatments that help to decrease the incidence in adult patients admitted to the emergency department in Al Gmail government public hospital in Libya.In this retrospective revaluation study, a total of 101 cases attended tothe emergency department during the study period from January 2010 to January 2015. Data were collected by studying records from the hospital emergency Center, were studied for gender, age, types of poisons, poisoning route, patient status (conscious, unconscious and semiconscious), treatment and antidote of poisoning, duration of hospital stay.There was significantly more common in females than males (M/F) ratiowas (0.4/0.61), Amongst the type of poison, bleach (sodium hypochlorite) poisoning founds the commonest cause (20.7%) and Alcohol accounted for (17.8%) and Food poisoning (14.8%) and benzene (13.9%) ware significantly more common than any other types of poisoning in this study.In our study, not all cases of intoxication were intended for self-harm,but the poisoning was accidental.

HTML FULL TEXT    PDF    XML 

Modulation of Pharmaceutical and Pharmacokinetic Attributes of Curcumin Encapsulated in Chitosan Using Spray Drying Technique

 

Roopa G, Venkatesh, Jayanthi C*, Hanumanthachar Joshi

Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysuru- 570004, Karnataka, India

Abstract

The present study is designed to formulate and characterize Curcumin (CUR) loaded Chitosan nanoparticles by ionic cross linking using TPP by employing spray drying technique to enhance the aqueous solubility, hence oral bio availability of Curcumin. Curcumin is very sparingly aqueous soluble, unstable in alkaline conditions and gets eliminated faster, resulting in poor bio availability. Curcumin in alcohol was used as drug loading solution. Tween 80 served as nano emulsifier and stabilizer. EE of optimized formulation F6 was found to be 98.5 ± 0.16 %. This formulation has an average particle size of 25 ± 0.1 nm. The Zeta potential of the formulation is -200 mV.  FTIR results revealed the absence of characteristic CUR peak in Curcumin Chitosan nanoparticles implying the successful incorporation of CUR into the Chitosan matrix. DSC thermograms witnessed that the crystalline form of CUR is transformed into amorphous form, having better dissolution and stability profile. SEM imaging of the nanosuspension formulation showed the topological features of the prepared nanoparticles. The nanoparticles were more spherical, discrete and homogeneous. % cumulative drug release studies exhibited very less drug release in Simulated Gastric Fluid (SGF- 3.97 %) and Simulated Intestinal Fluid (SIF - 4.2 %) exhibiting sustained release. Pure Curcumin showed burst release of approximately 95 % in 2 h in SGF with a decline in the concentration after 2 h in SIF due to significantly increased degradation in the alkaline conditions. The oral bioavailability (AUC) of Curcumin in female wistar rats increased 11-times following ingestion of Curcumin nanosuspension in comparison with conventional Curcumin suspension. The maximum concentration Cmax of 1034 ± 96 ng / ml for nanosuspension and 94 ± 9.4 ng / ml for Curcumin suspension and was observed at tmax of 2 h for both nanosuspension and suspension.

HTML FULL TEXT    PDF    XML