Mechanism of Action of Wound Healing Activity of Calendula officinalis: A Comprehensive Review

Bhargab Deka1, Bedanta Bhattacharjee1, Anshul Shakya1, Abu Md Ashif Ikbal2*, Chayanika Goswami3, Santa Sarma3

1Department of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh – 786 004, Assam, India
2Department of Pharmacy, Tripura University (A Central University), Suryamaninagar- 799022, Tripura (W), India
3Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Sciences- 781017

Received: 24-Oct-2020 , Accepted: 30-Dec-2020

Keywords: Calendula officinalis, Wound healing, Tissue regeneration


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Deka B, Bhattacharjee B, Shakya A, Ashif Ikbal AM, Goswami C, Sarma S. Mechanism of Action of Wound Healing Activity of Calendula officinalis: A Comprehensive Review. Pharmaceutical and Biosciences Journal. 2021; 9(1): 28-44.


Calendula officinalis is a short-lived aromatic herbaceous perennial plant. According to scientific literature, Calendula officinalis can also boost the wound healing activity. While the precise means it does is still unclear, it was assumed that the herb would increases the blood flow to the wound area, therefore supplying oxygen and nutrients necessary for tissue regeneration. The objective of the review is to understand and explore the relevant phytochemical and pharmacological information which will enhance it effective wound healing mechanism.  The data were identified using PubMed, Google Scholar, Scopus and bibliographic reviews of recent and old articles from an English literature search. After independent analysis by co-authors of the identified articles, data were analysed and extracted for the stated purpose.Calendula officinalis with its high quantity of flavonoids, it can help to minimize inflammation and speed up the healing process. Additional  usage for Calendula officinalis is that it can be a calming ointment, wash or tincture , since it can help to alleviate irritated wounds and minimize swelling and inflammation. Wound healing is a complex process, and Calendula officinalis have been historically used to treat minor wounds, skin irritation and minor burns. Data from large comparative clinical trials are needed before routine use can be recommended. Pharmacists and clinicians can effectively address patient questions about wound care and herbal therapies to help promote wound care practices that encourages wound healing and minimize poor outcomes such as infection or scaring.