Formulation Development and Evaluation of Gastro Retentive Matrix Tablet of Levamisole Hydrochloride

Shoaeb Mohammad Syed1*, Kiran Gawale1, ZS Farooqui2

1Assistant Professor, Dr. Vedprakash Patil Pharmacy College, Aurangabad MH, India
2Lecturer Kamala Nehru Polytechnic Pharmacy, Aurangabad MH, India

Received: 03-Oct-2020 , Accepted: 20-Jan-2021

Keywords: Gastroretentive, Levamisole HCl, Factorial design, HPMC, Carbopol, In vivo buoyancy


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How to Cite this Article

Syed SM, Gawale K, Farooqui ZS. Formulation Development and Evaluation of Gastro Retentive Matrix Tablet of Levamisole Hydrochloride. Pharmaceutical and Biosciences Journal. 2021; 9(1): 50-70.


The aim of current study was to develop suitable gastroretentive tablet of Levamisole HCl for prolonging the retention of Levamisole in stomach. Floating tablets were prepared by using HPMC K4M and Carbopol 934p in combination and their effect on floating, swelling and release of Levamisole HCl was studied. Optimization of drug release were carried out by taking different concentration of HPMC K4M and Carbopol 934p. It was found that HPMC and Carbopol with concentration 35% and 22% in tablet give satisfactory release and batch was selected for 32 factorial design. In this study all the formulation were subjected to physical evaluation parameter such as Hardness, Friability, content uniformity all were found to be within limits. In-vivo study F5 formulation was carried out to check the buoyancy of tablet. Tablet float in stomach of rabbit for 8 hours without adhering to gastric mucous. Stability studies of F5 formulation indicated that formulation is stable for 3 months at 40o C and 75% RH. The formulation retained its integrity and In-vitro performance.